Peyton Manning and his brothers on The Simpsons

Peyton still looks like Peyton after being Simpson-ized, but Eli and Cooper look different.

This is a clip from the episode "Oh Brother, Where Bart Thou":

Credit: TVFanatic0

And just for kicks, The Simpsons even had a Ryan Leaf cameo in one of their past episodes. If you don't know who Ryan Leaf is, he's considered to be the biggest NFL draft bust. He was drafted number 2 after Peyton Manning and some even thought he'd do better than Manning in pro football. However, after a couple of years in the NFL (he sucked balls), Leaf retired.

Credit: Mozicon